Effect of depression on Helicobacter pylori infection in patients with gastric cancer and its correlation with oncogene expression
Objective: To study the effect of depression on Helicobacter pylori (H. pylori) infection in patients with gastric cancer and its correlation with oncogene expression. Methods: A total of 82 patients who accepted radical operation for gastric cancer in Zigong Third People’s Hospital between March...
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-02-01
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| Series: | Journal of Hainan Medical University |
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| Online Access: | http://www.hnykdxxb.com/PDF/201722/21.pdf |
| Summary: | Objective: To study the effect of depression on Helicobacter pylori (H. pylori) infection in
patients with gastric cancer and its correlation with oncogene expression. Methods: A total of
82 patients who accepted radical operation for gastric cancer in Zigong Third People’s Hospital
between March 2015 and February 2017 were selected as the research subjects and divided
into depression group and non-depression group according to the preoperative HAMD scores,
and helicobacter pylori infection as well as the mRNA expression of proliferation genes and
invasion genes in gastric cancer lesions was detected. Results: The positive rate of H. pylori in
gastric cancer lesions of depression group was significantly higher than that of non-depression
group; LOXL2, RAB1A, UHRF1, Slug and ADAM8 mRNA expression in gastric cancer
lesions of depression group were significantly higher than those of non-depression group while
MTS1, NOX, E-cadherin and TIMP1 mRNA expression were significantly lower than those of
non-depression group; LOXL2, RAB1A, UHRF1, Slug and ADAM8 mRNA expression in H.
pylori-positive gastric cancer lesions of depression group were significantly higher than those
in H. pylori-negative gastric cancer lesions of depression group while MTS1, NOX, E-cadherin
and TIMP1 mRNA expression were significantly lower than those in H. pylori-negative gastric
cancer lesions of depression group. Conclusion: Depression can increase the H. pylori infection
rate and promote the proliferation and invasion of cancer cells in gastric cancer lesions. |
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| ISSN: | 1007-1237 1007-1237 |