Microbial eczema: possibilities of correction at the present stage

• Main Authors: M. M. Tlish, T. G. Kuznetsova, Z. Yu. Naatyzh, F. A. Psavok
• Format: Article
• Language: Russian
• Published: State Scientific Center of Dermatovenereology and Cosmetology 2018-12-01
• Series: Vestnik Dermatologii i Venerologii
• Subjects: microbial eczema; topical therapy
• Online Access: https://www.vestnikdv.ru/jour/article/view/425

Microbial eczema is a chronic recurrent dermatosis characterized by evolutionary polymorphism of the elements of the rash, sputum, itching, allergic reaction of the sensitized skin to the products of the decay of microorganisms and their toxins, developing against the background of a long-existing pyogenic focus in violation of the most important regulatory systems of the body.Purpose: to study the biocenosis of the skin in patients with microbial eczema and to evaluate the clinical efficacy and safety of the cream “Tetraderm” in such patients.Materials and methods. Patients with microbial eczema were observed, randomly selected into two groups. All patients studied biocenosis of the skin before and after treatment. Patients of the study group received topical therapy with the cream “Tetraderm”. External therapy for patients of the comparison group was carried out with cream of mometasone furoate in combination with erythromycin and clotrimazole ointments. The effectiveness of the therapy was evaluated taking into account the clinical dynamics of the skin process, bacteriological data on the content of pustules and detachable erosion, calculation of the EASI and DIJ indices.Results. A comparative analysis of the biocenosis of microbial eczema foci in patients of both groups at the end of therapy showed a higher severity of disbiotic changes in the comparison group. As a result of our study found that patients who used the cream “Tetraderm”, there was a more rapid regression of dermatosis, almost complete suppression of pathogenic bacterial flora, a significant improvement in the quality of life.Conclusion. The biocenosis of the skin of patients with microbial eczema was characterized by a high degree of contamination of Staphylococcus aureus and Staphylococcus epidermidis, against the background of the average verification of Streptococcus spp., Candida spp. The combination of pronounced anti-inflammatory, antibacterial, antimicotic and regenerating effects of the cream “Tetraderm” causes its high efficiency and prospects of use as a drug of choice of topical monotherapy of microbial eczema.