Targeting of IL-10R on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells

Abstract Acute myeloid leukemia (AML) is a biologically and clinically heterogeneous disease with a dismal prognosis and limited treatment options. Chimeric antigen receptor (CAR) T cells have achieved unprecedented clinical responses in patients with B cell malignancies but a dismal consequences in...

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Bibliographic Details
Main Authors: Nianci Chen, Yingxi Xu, Junli Mou, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, Min Wang, Jiangxiang Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-021-00536-x