Oxidized low density lipoprotein, stem cells, and atherosclerosis

• Main Authors: Yang Hui, Mohamed Ahmed Salah, Zhou Sheng-hua
• Format: Article
• Language: English
• Published: BMC 2012-07-01
• Series: Lipids in Health and Disease
• Subjects: Oxidized LDL; Stem cells; Atherosclerosis; LOX-1; Oxidative stress
• Online Access: http://www.lipidworld.com/content/11/1/85

<p>Abstract</p> <p>Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflammation accompanied with vascular injury. Researchers have proposed that stem cells participate in the formation of atherosclerotic plaque. Also, because ox-LDL is capable of inducing toxic effects on stem cells, it is reasonable to postulate that ox-LDL promotes the progress of atherosclerosis via acting on stem cells. In the present article, we review the relationship between ox-LDL, stem cells, and atherosclerosis and a portion of the associated mechanisms.</p>