Deletion at 2q14.3 is associated with worse response to TNF-α blockers in patients with rheumatoid arthritis

Deletion at 2q14.3 is associated with worse response to TNF-α blockers in patients with rheumatoid arthritis

Abstract Background Structural variations such as copy number variations (CNVs) have a functional impact on various human traits. This study profiled genome-wide CNVs in Korean patients with rheumatoid arthritis (RA) to investigate the efficacy of treatment with TNF-α blockers. Methods A total of 35...

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Bibliographic Details
Main Authors: Ki-Nam Gu, So-Young Bang, Hye-Soon Lee, Youngho Park, Ju-Yeon Kang, Ji-Soong Kim, Bora Nam, Hyun-Seung Yoo, Jung-Min Shin, Yeon-Kyung Lee, Tae-Han Lee, Sehwan Chun, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Kwangwoo Kim, Sang-Cheol Bae
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Copy number variations
TNF-α blockers
Drug efficacy
Online Access:http://link.springer.com/article/10.1186/s13075-019-1983-y

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