Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine

Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine

<p>Abstract</p> <p>Two studies recently reported around 10% of <it>EGFR </it>activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients....

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Main Authors: Lamy Pierre-Jean, Jacot William
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Diagnostic Pathology
Subjects:
Breast Cancer
EGFR
activating mutations
triple negative
geographic variations
Online Access:http://www.diagnosticpathology.org/content/7/1/13
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spelling doaj-ebdad9fe00b349e7832e49240b15f9352020-11-24T23:26:35ZengBMCDiagnostic Pathology1746-15962012-02-01711310.1186/1746-1596-7-13Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicineLamy Pierre-JeanJacot William<p>Abstract</p> <p>Two studies recently reported around 10% of <it>EGFR </it>activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the <it>EGFR </it>mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies.</p> http://www.diagnosticpathology.org/content/7/1/13Breast CancerEGFRactivating mutationstriple negativegeographic variations
collection DOAJ
language English
format Article
sources DOAJ
author Lamy Pierre-Jean
Jacot William
spellingShingle Lamy Pierre-Jean
Jacot William
Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
Diagnostic Pathology
Breast Cancer
EGFR
activating mutations
triple negative
geographic variations
author_facet Lamy Pierre-Jean
Jacot William
author_sort Lamy Pierre-Jean
title Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
title_short Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
title_full Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
title_fullStr Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
title_full_unstemmed Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
title_sort worldwide variations in <it>egfr </it>somatic mutations: a challenge for personalized medicine
publisher BMC
series Diagnostic Pathology
issn 1746-1596
publishDate 2012-02-01
description <p>Abstract</p> <p>Two studies recently reported around 10% of <it>EGFR </it>activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the <it>EGFR </it>mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies.</p>
topic Breast Cancer
EGFR
activating mutations
triple negative
geographic variations
url http://www.diagnosticpathology.org/content/7/1/13
work_keys_str_mv AT lamypierrejean worldwidevariationsinitegfritsomaticmutationsachallengeforpersonalizedmedicine
AT jacotwilliam worldwidevariationsinitegfritsomaticmutationsachallengeforpersonalizedmedicine
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