Worldwide variations in <it>EGFR </it>somatic mutations: a challenge for personalized medicine
<p>Abstract</p> <p>Two studies recently reported around 10% of <it>EGFR </it>activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-02-01
|
| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://www.diagnosticpathology.org/content/7/1/13 |
| Summary: | <p>Abstract</p> <p>Two studies recently reported around 10% of <it>EGFR </it>activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the <it>EGFR </it>mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies.</p> |
|---|---|
| ISSN: | 1746-1596 |