An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin

The interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivatedin vivo using click chemistry, paving the way to the design of drugs with tunable in vivoproperties.

Bibliographic Details
Main Authors:	Sylvain Ursuegui, Marion Recher, Wojciech Krężel, Alain Wagner
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15242

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spelling	doaj-ebda2b9fe32443d9b94c7789c96664922021-05-11T07:05:31ZengNature Publishing GroupNature Communications2041-17232017-05-01811810.1038/ncomms15242An in vivo strategy to counteract post-administration anticoagulant activity of azido-WarfarinSylvain Ursuegui0Marion Recher1Wojciech Krężel2Alain Wagner3Laboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of StrasbourgLaboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of StrasbourgInstitut de Génétique et de Biologie Moléculaire et CellulaireLaboratory of Functional Chemo-Systems (UMR 7199), Labex Medalis, University of StrasbourgThe interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivatedin vivo using click chemistry, paving the way to the design of drugs with tunable in vivoproperties.https://doi.org/10.1038/ncomms15242
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sylvain Ursuegui Marion Recher Wojciech Krężel Alain Wagner
spellingShingle	Sylvain Ursuegui Marion Recher Wojciech Krężel Alain Wagner An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin Nature Communications
author_facet	Sylvain Ursuegui Marion Recher Wojciech Krężel Alain Wagner
author_sort	Sylvain Ursuegui
title	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_short	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_full	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_fullStr	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_full_unstemmed	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_sort	in vivo strategy to counteract post-administration anticoagulant activity of azido-warfarin
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	The interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivatedin vivo using click chemistry, paving the way to the design of drugs with tunable in vivoproperties.
url	https://doi.org/10.1038/ncomms15242
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An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin

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