SPARC Negatively Correlates With Prognosis After Transarterial Chemoembolization and Facilitates Proliferation and Metastasis of Hepatocellular Carcinoma via ERK/MMP Signaling Pathways

SPARC Negatively Correlates With Prognosis After Transarterial Chemoembolization and Facilitates Proliferation and Metastasis of Hepatocellular Carcinoma via ERK/MMP Signaling Pathways

Background: Transarterial chemoembolization (TACE) represents a widely accepted treatment procedure for intermediate stage or unresectable hepatocellular carcinoma (HCC). However, few studies have evaluated serologic prognosis factors in patients with HCC before TACE. Secreted protein acidic and ric...

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Bibliographic Details
Main Authors: Yao Liu, Ying Feng, Xiaojing Wang, Xue Yang, Ying Hu, Yuxin Li, Qun Zhang, Yunyi Huang, Ke Shi, Chongping Ran, Jie Hou, Li Jiang, Junfa Li, Xianbo Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
transarterial chemoembolization
secreted protein acidic and rich in cysteine
extracellular signal-regulated kinase
matrix metalloproteinase
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00813/full

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