Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Lymphocyte transendothelial migration (TEM) relies on ICAM-1 engagement on the luminal surface of the endothelial cells (ECs). In blood–brain barrier (BBB) ECs, ICAM-1 triggers TEM signalling, including through JNK MAP kinase and AMP-activated protein kinase (AMPK), which lead to the phosphorylation...

Full description

Bibliographic Details
Main Authors:	Silvia Dragoni, Anna Papageorgiou, Caroline Araiz, John Greenwood, Patric Turowski
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Cells
Subjects:	lymphocyte transendothelial migration blood–brain barrier protease-activated receptor 1 AMP-activated protein kinase endothelial nitric oxide synthase
Online Access:	https://www.mdpi.com/2073-4409/9/12/2723

Similar Items

Protein Disulphide Isomerase A1 Is Involved in the Regulation of Breast Cancer Cell Adhesion and Transmigration via Lung Microvascular Endothelial Cells
by: Marta Stojak, et al.
Published: (2020-10-01)

Chronic nitrite treatment activates adenosine monophosphate-activated protein kinase-endothelial nitric oxide synthase pathway in human aortic endothelial cells
by: Yang Liu, et al.
Published: (2021-05-01)

Kang Le Xin Reduces Blood Pressure Through Inducing Endothelial-Dependent Vasodilation by Activating the AMPK-eNOS Pathway
by: Yixiu Zhao, et al.
Published: (2020-01-01)

AMPKα1-Sensitivity of Orai1 and Ca2+ Entry in T - Lymphocytes
by: Shefalee K. Bhavsar, et al.
Published: (2013-09-01)

Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
by: S. Dijkstra, et al.
Published: (2008-09-01)

Preserved microvascular endothelial function in young, obese adults with functional loss of nitric oxide signaling
by: John eHarrell, et al.
Published: (2015-12-01)

Differentiation and Transmigration of CD4 T Cells in Neuroinflammation and Autoimmunity
by: Sandip Ashok Sonar, et al.
Published: (2017-11-01)

LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro
by: Ghislin Stephanie, et al.
Published: (2012-10-01)

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2
by: Qin Zhou, et al.
Published: (2018-08-01)

Estetrol modulates endothelial nitric oxide synthesis in human endothelial cells
by: Maria Magdalena eMontt-Guevara, et al.
Published: (2015-07-01)

Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation
by: Moriah E. Katt, et al.
Published: (2018-02-01)

Characteristic of no-synthase of peripheral blood lymphocytes of patients with rheumatic pathology
by: Ulyana Efremova, et al.
Published: (2015-03-01)

Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway
by: Yingshuai Zhao, et al.
Published: (2017-05-01)

In Vitro Studies on the Trafficking of Dendritic CellsThrough Endothelial Cells and Extra-Cellular Matrix
by: Giancarlo Bianchi, et al.
Published: (2000-01-01)

SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1
by: Karen Y. Fung, et al.
Published: (2017-10-01)

Sodium salicylate prevents inflammation-associated decreases in phosphorylated-Enos SER1177 in human aortic endothelial cells through an AMPK-dependent mechanism
by: Siefers, Kyle John
Published: (2014)

Crocin Improves the Endothelial Function Regulated by Kca3.1 Through ERK and Akt Signaling Pathways
by: Huike Yang, et al.
Published: (2018-03-01)

Еxpression of cerebral endothelial NLRP3 inflammasome in viral inflammation in vitro
by: A. B. Salmina, et al.
Published: (2018-01-01)

Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation
by: Nina Zippel, et al.
Published: (2018-09-01)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
by: V. P. Deryagina, et al.
Published: (2021-07-01)

Nipah Virus Infection of Immature Dendritic Cells Increases Its Transendothelial Migration Across Human Brain Microvascular Endothelial Cells
by: Vunjia Tiong, et al.
Published: (2018-11-01)

Association of Variable Number of Tandem Repeats in Endothelial Nitric Oxide Synthase Gene with Coronary Artery Disease
by: S Salimi, et al.
Published: (2006-08-01)

Association of Variable Number of Tandem Repeats in Endothelial Nitric Oxide Synthase Gene with Coronary Artery Disease
by: S Salimi, et al.
Published: (2006-12-01)

Clinical aspects of endothelial NO-synthase gene polymorphism in professional sportsmen (literature review)
by: S. N. Malakhova
Published: (2016-08-01)

Association of endothelial nitric oxide synthase gene variants with preeclampsia
by: Ghazala Shaheen, et al.
Published: (2021-07-01)

Endothelial-Derived Interleukin-1α Activates Innate Immunity by Promoting the Bactericidal Activity of Transendothelial Neutrophils
by: Xiaoye Liu, et al.
Published: (2020-07-01)

Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier
by: Aniela Bittner, et al.
Published: (2021-02-01)

Tissue Factor-Expressing Tumor-Derived Extracellular Vesicles Activate Quiescent Endothelial Cells via Protease-Activated Receptor-1
by: Sara P. Y. Che, et al.
Published: (2017-11-01)

Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma
by: Ting Xiao, et al.
Published: (2018-08-01)

Effect of platelet microvesicles on the function of human microvascular endothelial cells
by: PAN Lina, et al.
Published: (2020-04-01)

An In Vitro Study on the Role of Endothelial Cell Connexin43 Gap Junctions in the Regulation of Hematopoietic Stem and Progenitor Cells Traffic
by: Pirman, Megan
Published: (2010)

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
by: John J. Jamieson, et al.
Published: (2019-06-01)

Regulation of Endothelial Phenotype in Rat Soleus Muscle Feed Arteries: Influence of Aging and Exercise Training
by: Trott, Daniel Wayne
Published: (2012)

Endothelial Cell Focal Adhesion Regulates Transendothelial Migration and Subendothelial Crawling of T Cells
by: Jaehyun Lee, et al.
Published: (2018-01-01)

Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells
by: Hung-Hsing Chao, et al.
Published: (2017-11-01)

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
by: Ismail Sari, et al.

Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism in Renal Transplant Recipients
by: N Azarpira, et al.
Published: (2011-04-01)

Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?
by: Ismail Sari, et al.
Published: (2013-01-01)

PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
by: O. I. Stepanova, et al.
Published: (2014-07-01)

Regulation of Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk With Nitric Oxide
by: Yoon Kyung Choi, et al.
Published: (2021-04-01)