Enhanced Detection of DNA Viruses in the Cerebrospinal Fluid of Encephalitis Patients Using Metagenomic Next-Generation Sequencing

Enhanced Detection of DNA Viruses in the Cerebrospinal Fluid of Encephalitis Patients Using Metagenomic Next-Generation Sequencing

The long and expanding list of viral pathogens associated with causing encephalitis confounds current diagnostic procedures, and in up to 50% of cases, the etiology remains undetermined. Sequence-agnostic metagenomic next-generation sequencing (mNGS) obviates the need to specify targets in advance a...

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Bibliographic Details
Main Authors: Carmen F. Manso, David F. Bibby, Hodan Mohamed, David W. G. Brown, Mark Zuckerman, Jean L. Mbisa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
metagenomics
next-generation sequencing
encephalitis
DNA viruses
diagnostic techniques
bioinformatics
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01879/full

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