Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

Abstract Background The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders. Methods This study investigated the roles of TGR5 activation in attenuating BBB dama...

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Bibliographic Details
Main Authors: Hui Liang, Nate Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo, John H. Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Biomedical Science
Subjects:
TGR5
Blood-brain barrier
Neuroprotection
BRCA1
Sirt1
Middle cerebral artery occlusion
Online Access:http://link.springer.com/article/10.1186/s12929-020-00656-9

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