Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects

Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects

Upregulation of Ca2+-permeable AMPA receptors (CP-AMPARs) in the dorsal horn neurons of the spinal cord has been causally linked to the maintenance of persistent inflammatory pain. Therefore, inhibition of CP-AMPARs could potentially alleviate an, otherwise, poorly treatable chronic pain. However, a...

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Bibliographic Details
Main Authors: Olga eKopach, Volodymyr eKrotov, Julia eGoncharenko, Nana eVoitenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dorsal horn
antinociception
Ca2+-permeable AMPA receptors
dicationic compounds
persistent inflammatory pain
the activity-dependent inhibition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00050/full

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