Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide

Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide

There is increasing evidence that the fast-inactivating potassium current IA, encoded by KV3. 4 channels, plays an important role in Alzheimer's Disease (AD), since the neurotoxic β-amyloid peptide1-42 (Aβ1−42) increases the IA current triggering apoptotic processes. The specific inhibition of...

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Bibliographic Details
Main Authors: Roselia Ciccone, Ilaria Piccialli, Paolo Grieco, Francesco Merlino, Lucio Annunziato, Anna Pannaccione
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Chemistry
Subjects:
BDS-I
voltage gated potassium channel
KV3.4
Alzheimer's disease
Aβ peptide
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00479/full

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