APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.

APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.

BACKGROUND: Besides regulation of actin cytoskeleton-dependent functions, Rho GTPase pathways are essential to cell cycle progression and cell division. Rho, Rac and Cdc42 regulate G1 to S phase progression and are involved in cytokinesis. RhoA GDP/GTP cycling is required for normal cytokinesis and...

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Bibliographic Details
Main Authors: Caroline Liot, Laetitia Seguin, Aurélie Siret, Catherine Crouin, Susanne Schmidt, Jacques Bertoglio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3158779?pdf=render

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