ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells

ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells

IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and functi...

Full description

Bibliographic Details
Main Authors: Weishan Huang, Sabrina Solouki, Nicholas Koylass, Song-Guo Zheng, Avery August
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15871
id doaj-eb63136b19fd40fbb0f60255832a0ecd
record_format Article
spelling doaj-eb63136b19fd40fbb0f60255832a0ecd2021-05-11T07:37:26ZengNature Publishing GroupNature Communications2041-17232017-06-018111510.1038/ncomms15871ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cellsWeishan Huang0Sabrina Solouki1Nicholas Koylass2Song-Guo Zheng3Avery August4Center for Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Microbiology and Immunology, Cornell UniversityDepartment of Microbiology and Immunology, Cornell UniversityCenter for Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Microbiology and Immunology, Cornell UniversityIL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and function of Tr1 cells.https://doi.org/10.1038/ncomms15871
collection DOAJ
language English
format Article
sources DOAJ
author Weishan Huang
Sabrina Solouki
Nicholas Koylass
Song-Guo Zheng
Avery August
spellingShingle Weishan Huang
Sabrina Solouki
Nicholas Koylass
Song-Guo Zheng
Avery August
ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
Nature Communications
author_facet Weishan Huang
Sabrina Solouki
Nicholas Koylass
Song-Guo Zheng
Avery August
author_sort Weishan Huang
title ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_short ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_full ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_fullStr ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_full_unstemmed ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells
title_sort itk signalling via the ras/irf4 pathway regulates the development and function of tr1 cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and function of Tr1 cells.
url https://doi.org/10.1038/ncomms15871
work_keys_str_mv AT weishanhuang itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells
AT sabrinasolouki itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells
AT nicholaskoylass itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells
AT songguozheng itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells
AT averyaugust itksignallingviatherasirf4pathwayregulatesthedevelopmentandfunctionoftr1cells
_version_ 1721451952549658624

Similar Items