Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers

Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers

Abstract Background Doxorubicin chemotherapy is used across a range of adult and pediatric malignancies. Cardiac toxicity is common, and dysfunction develops over time in many patients. Biomarkers used for predicting late cardiac dysfunction following doxorubicin exposure have shown promise. Preclin...

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Bibliographic Details
Main Authors: Andrew Poklepovic, Yuesheng Qu, Molly Dickinson, Michael C. Kontos, Maciej Kmieciak, Elizabeth Schultz, Dipankar Bandopadhyay, Xiaoyan Deng, Rakesh C. Kukreja
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cardio-Oncology
Subjects:
Cardioprotection
Chemotherapy
Biomarker
Clinical trial
Ejection fraction
Strain
Online Access:http://link.springer.com/article/10.1186/s40959-018-0033-2

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