Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment

• Main Authors: Min Hee Park, Bosung Baek, Hee Kyung Jin, Jae-sung Bae
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2018-09-01
• Series: Animal Cells and Systems
• Subjects: Bone marrow damage; bone marrow microenvironment cells; Chemotherapy; hematopoietic stem cell; neuropeptide Y-derived recombinant peptides
• Online Access: http://dx.doi.org/10.1080/19768354.2018.1517826

Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy.