Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study

• Main Authors: Elizama de Gregório, Luan Henrique Patrzyk, Anne Karine Bosetto Fiebrantz, Juliana Sartori Bonini, Dayanna Hartmann Cambruzzi, Camila Diedrich, Bárbara Luisa Fermino, Roberta Fabbri, Weber Cláudio Francisco Nunes da Silva
• Format: Article
• Language: English
• Published: Associação Médica Brasileira
• Series: Revista da Associação Médica Brasileira
• Subjects: Doença de Alzheimer; Obesidade; Macronutrientes; Demência
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200222&lng=en&tlng=en

SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested.