Chemical transformations of new mono- and bis-derivatives of spiroindol-3,3’-pyrrolo[3,4-c]pyrrole based on bis-maleiminides and the study of the microbiological activity of the compounds synthesized

Chemical transformations of new mono- and bis-derivatives of spiroindol-3,3’-pyrrolo[3,4-c]pyrrole based on bis-maleiminides and the study of the microbiological activity of the compounds synthesized

Aim. To synthesize new derivatives based on hexamethylene(ethylene)-N,N’-bis(spiroindole-3,3’-pyrrolo-[3,4-c]pyrrole-2a,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trions) and 1’-(m-phenylene-N-maleimidido)-2a’,5a’-dihydro-1’H- spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-2,2’,6’(1H,1’H,5’H)-trions by modifying the N...

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Bibliographic Details
Main Authors: Yevheniia I. Siumka, Konstantin M. Sytnik, Dmitriy V. Levashov, Tamara V. Spychak, Vladimir D. Horiachyi, Leonid A. Shemchuk
Format: Article
Language:English
Published: National University of Pharmacy (Kharkiv, Ukraine) 2019-12-01
Series:Журнал органічної та фармацевтичної хімії
Subjects:
bis-spirocyclic systems
2-oxindole
alkylation
acylation
nitrosation
antimicrobial activity
Online Access:http://ophcj.nuph.edu.ua/article/view/ophcj.19.181138/185174

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