| Summary: | Abstract Background Cancer patients are accompanied with high morbidity of depression, and gender effects are known to inhabit in the depressive episodes. This study aimed to explore the gender effects in cancer patients, and the relationship between gender-cancer factors and the depression symptoms. Methods The 18F-FDG PET scans of 49 cancer patients and 48 normal controls were included. We used voxel-wise analysis to explore the effects of cancer factor and gender factor in cerebral glucose metabolism. Beck Depression Inventory was utilized to quantify the depression symptoms in cancer patients. Results Our results showed significant cancer main effects primarily in superior frontal gyrus and parietal gyrus; and significant gender main effects primarily in cerebellum posterior lobe, inferior temporal gyrus. Significant gender-by-cancer interaction effects were also observed, which primarily located in superior frontal gyrus. We showed the metabolic intensities of the 5 aforementioned clusters were related to the mental stress of depressive emotion. Conclusions Our results suggested that males and females have different psychological endurance when facing cancer diagnosis or preventing depression. Furthermore, the cerebral abnormal metabolism might serve as a depressive indicator for cancer patients. The present findings provided supporting evidence for abnormal cerebral glucose metabolism affected by gender factor in cancer patients with mental stress of depressive emotion, and these brain regions should be concerned in clinic.
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