A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion

The mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and ins...

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Main Authors:	Michael J. Texada, Anne F. Jørgensen, Christian F. Christensen, Takashi Koyama, Alina Malita, Daniel K. Smith, Dylan F. M. Marple, E. Thomas Danielsen, Sine K. Petersen, Jakob L. Hansen, Kenneth A. Halberg, Kim F. Rewitz
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09943-y

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spelling	doaj-eb1d36697d6243149fc5a3d90944c2022021-05-11T12:15:58ZengNature Publishing GroupNature Communications2041-17232019-04-0110111610.1038/s41467-019-09943-yA fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretionMichael J. Texada0Anne F. Jørgensen1Christian F. Christensen2Takashi Koyama3Alina Malita4Daniel K. Smith5Dylan F. M. Marple6E. Thomas Danielsen7Sine K. Petersen8Jakob L. Hansen9Kenneth A. Halberg10Kim F. Rewitz11Department of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenCardiovascular Research, Department number 5377, Novo Nordisk A/SDepartment of Biology, University of CopenhagenDepartment of Biology, University of CopenhagenThe mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and insulin secretion.https://doi.org/10.1038/s41467-019-09943-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michael J. Texada Anne F. Jørgensen Christian F. Christensen Takashi Koyama Alina Malita Daniel K. Smith Dylan F. M. Marple E. Thomas Danielsen Sine K. Petersen Jakob L. Hansen Kenneth A. Halberg Kim F. Rewitz
spellingShingle	Michael J. Texada Anne F. Jørgensen Christian F. Christensen Takashi Koyama Alina Malita Daniel K. Smith Dylan F. M. Marple E. Thomas Danielsen Sine K. Petersen Jakob L. Hansen Kenneth A. Halberg Kim F. Rewitz A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion Nature Communications
author_facet	Michael J. Texada Anne F. Jørgensen Christian F. Christensen Takashi Koyama Alina Malita Daniel K. Smith Dylan F. M. Marple E. Thomas Danielsen Sine K. Petersen Jakob L. Hansen Kenneth A. Halberg Kim F. Rewitz
author_sort	Michael J. Texada
title	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_short	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_full	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_fullStr	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_full_unstemmed	A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
title_sort	fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	The mechanisms by which organisms adapt their growth according to the availability of oxygen are incompletely understood. Here the authors identify the D rosophila fat body as a tissue regulating growth in response to oxygen sensing via a mechanism involving Hph inhibition, HIF1-a activation and insulin secretion.
url	https://doi.org/10.1038/s41467-019-09943-y
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A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion

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