Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients

• Main Authors: Alberto Rodrigo, Jorge L. Ojeda, Sonia Vega, Oscar Sanchez-Gracia, Angel Lanas, Dolores Isla, Adrian Velazquez-Campoy, Olga Abian
• Format: Article
• Language: English
• Published: MDPI AG 2019-07-01
• Series: Cancers
• Subjects: liquid biopsy; lung cancer; serum sample; differential scanning calorimetry; generalized linear models; cancer screening program
• Online Access: https://www.mdpi.com/2072-6694/11/7/1012

Risk population screening programs are instrumental for advancing cancer management and reducing economic costs of therapeutic interventions and the burden of the disease, as well as increasing the survival rate and improving the quality of life for cancer patients. Lung cancer, with high incidence and mortality rates, is not excluded from this situation. The success of screening programs relies on many factors, with some of them being the appropriate definition of the risk population and the implementation of detection techniques with an optimal discrimination power and strong patient adherence. Liquid biopsy based on serum or plasma detection of circulating tumor cells or DNA/RNA is increasingly employed nowadays, but certain limitations constrain its wide application. In this work, we present a new implementation of thermal liquid biopsy (TLB) for lung cancer patients. TLB provides a prediction score based on the ability to detect plasma/serum proteome alterations through calorimetric thermograms that strongly correlates with the presence of lung cancer disease (91% accuracy rate, 90% sensitivity, 92% specificity, diagnostic odds ratio 104). TLB is a quick, minimally-invasive, low-risk technique that can be applied in clinical practice for evidencing lung cancer, and it can be used in screening and monitoring actions.