Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx pla...

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Main Authors:	Yusuke Hosoi, Miki Soma, Hirosuke Shiura, Takashi Sado, Hidetoshi Hasuwa, Kuniya Abe, Takashi Kohda, Fumitoshi Ishino, Shin Kobayashi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06327-6

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spelling	doaj-eb168a2bde444d00baa2da1b1bb42af52021-05-11T09:34:08ZengNature Publishing GroupNature Communications2041-17232018-09-019111310.1038/s41467-018-06327-6Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotypeYusuke Hosoi0Miki Soma1Hirosuke Shiura2Takashi Sado3Hidetoshi Hasuwa4Kuniya Abe5Takashi Kohda6Fumitoshi Ishino7Shin Kobayashi8Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Bioscience, Graduate School of Agriculture, Kindai UniversityResearch Institute for Microbial Diseases, Osaka UniversityTechnology and Development Team for Mammalian Genome Dynamics, RIKEN BioResource Research CenterDepartment of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx plays a role in gene silencing on the inactive X chromosome.https://doi.org/10.1038/s41467-018-06327-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yusuke Hosoi Miki Soma Hirosuke Shiura Takashi Sado Hidetoshi Hasuwa Kuniya Abe Takashi Kohda Fumitoshi Ishino Shin Kobayashi
spellingShingle	Yusuke Hosoi Miki Soma Hirosuke Shiura Takashi Sado Hidetoshi Hasuwa Kuniya Abe Takashi Kohda Fumitoshi Ishino Shin Kobayashi Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype Nature Communications
author_facet	Yusuke Hosoi Miki Soma Hirosuke Shiura Takashi Sado Hidetoshi Hasuwa Kuniya Abe Takashi Kohda Fumitoshi Ishino Shin Kobayashi
author_sort	Yusuke Hosoi
title	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_short	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_full	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_fullStr	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_full_unstemmed	Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype
title_sort	female mice lacking ftx lncrna exhibit impaired x-chromosome inactivation and a microphthalmia-like phenotype
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx plays a role in gene silencing on the inactive X chromosome.
url	https://doi.org/10.1038/s41467-018-06327-6
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Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

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