Insulin resistance and lipid transport system in fasting normoglycemia

• Main Authors: O. V. Alexandrovich, I. N. Ozerova, N. V. Perova, V. A. Metelskaya, A. M. Olferyev, G. N. Shchukina
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2007-10-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: insulin resistance; dyslipoproteinemia; hdl lipid-protein components; normoglycemia
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1357
• ISSN: 1728-8800; 2619-0125

Aim. To investigate the link between insulin resistance (IR) and lipid transport system in patients with fasting normoglycemia. Material and methods. In 39 patients aged 2070 years, with fasting normoglycemia, the levels of lipids, apolipoproteins (apo), and IR parameters (insulin sensitivity index; ISI McAuley, HOMA-IR) were measured. Results. In patients with fasting normoglycemia and low ISI McAuley, atherogenic dyslipoproteinemia was observed: increased triglycerides, apo B, apo B/apo AI levels, reduced low-density lipoprotein particle size; disturbed high-density lipoprotein (HDL)-mediated cholesterol (CH) transport: reduced levels of free and esterified HDL-CH, phospholipids, apo A1, decreased HDL-CH particle loading, increased apo AII/apo AI concentration ratio. Conclusion. In patients with fasting normoglycemia, diagnosing latent carbohydrate metabolism disturbances, which are associated with lipid transport system abnormalities and potentially increased risk of coronary heart disease or Type 2 diabetes mellitus, provides an opportunity for early metabolic correction.