AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.

AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.

The hotspot AKT1E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6-2% of human lung cancers. Recently, we have demonstrated that AKT1E17K transforms immortalized human bronchial cells. Here by use of a transgenic Cre-inducible murine strain in the wild type Rosa26 (R...

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Main Authors: Donatella Malanga, Stefania Belmonte, Fabiana Colelli, Marzia Scarfò, Carmela De Marco, Duarte Mendes Oliveira, Teresa Mirante, Caterina Camastra, Monica Gagliardi, Antonia Rizzuto, Chiara Mignogna, Orlando Paciello, Serenella Papparella, Henrik Fagman, Giuseppe Viglietto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4747507?pdf=render

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