Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Plasma levels of neurological proteins have the potential to serve as biomarkers for neurological conditions. Here, Hillary et al. perform genome- and epigenome-wide association studies for 92 neurological proteins and identify 41 genomic loci for 33 proteins and 26 CpG sites for 9 proteins.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11177-x |
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doaj-eb036a77eede4ca581fe18fef08693112021-05-11T11:40:43ZengNature Publishing GroupNature Communications2041-17232019-07-011011910.1038/s41467-019-11177-xGenome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936Robert F. Hillary0Daniel L. McCartney1Sarah E. Harris2Anna J. Stevenson3Anne Seeboth4Qian Zhang5David C. Liewald6Kathryn L. Evans7Craig W. Ritchie8Elliot M. Tucker-Drob9Naomi R. Wray10Allan F. McRae11Peter M. Visscher12Ian J. Deary13Riccardo E. Marioni14Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghInstitute for Molecular Bioscience, University of QueenslandCentre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of EdinburghDepartment of Psychology, The University of Texas at AustinInstitute for Molecular Bioscience, University of QueenslandInstitute for Molecular Bioscience, University of QueenslandInstitute for Molecular Bioscience, University of QueenslandCentre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghPlasma levels of neurological proteins have the potential to serve as biomarkers for neurological conditions. Here, Hillary et al. perform genome- and epigenome-wide association studies for 92 neurological proteins and identify 41 genomic loci for 33 proteins and 26 CpG sites for 9 proteins.https://doi.org/10.1038/s41467-019-11177-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Robert F. Hillary Daniel L. McCartney Sarah E. Harris Anna J. Stevenson Anne Seeboth Qian Zhang David C. Liewald Kathryn L. Evans Craig W. Ritchie Elliot M. Tucker-Drob Naomi R. Wray Allan F. McRae Peter M. Visscher Ian J. Deary Riccardo E. Marioni |
| spellingShingle |
Robert F. Hillary Daniel L. McCartney Sarah E. Harris Anna J. Stevenson Anne Seeboth Qian Zhang David C. Liewald Kathryn L. Evans Craig W. Ritchie Elliot M. Tucker-Drob Naomi R. Wray Allan F. McRae Peter M. Visscher Ian J. Deary Riccardo E. Marioni Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936 Nature Communications |
| author_facet |
Robert F. Hillary Daniel L. McCartney Sarah E. Harris Anna J. Stevenson Anne Seeboth Qian Zhang David C. Liewald Kathryn L. Evans Craig W. Ritchie Elliot M. Tucker-Drob Naomi R. Wray Allan F. McRae Peter M. Visscher Ian J. Deary Riccardo E. Marioni |
| author_sort |
Robert F. Hillary |
| title |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936 |
| title_short |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936 |
| title_full |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936 |
| title_fullStr |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936 |
| title_full_unstemmed |
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936 |
| title_sort |
genome and epigenome wide studies of neurological protein biomarkers in the lothian birth cohort 1936 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Plasma levels of neurological proteins have the potential to serve as biomarkers for neurological conditions. Here, Hillary et al. perform genome- and epigenome-wide association studies for 92 neurological proteins and identify 41 genomic loci for 33 proteins and 26 CpG sites for 9 proteins. |
| url |
https://doi.org/10.1038/s41467-019-11177-x |
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