Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
Objective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-sta...
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doaj-eb01f72ce8df417898d27e7b8f24c38b2020-11-25T00:53:20ZengHindawi LimitedInternational Journal of Nephrology2090-21582010-01-01201010.4061/2010/612126612126Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant RecipientsGuang-chun Wang0Jun-hua Zheng1Long-gen Xu2Zhi-lian Min3You-hua Zhu4Jun Qi5Qiang-lin Duan6Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaKidney Transplantation Center, 117th Hospital of PLA, Hangzhou 310013, ChinaDepartment of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, ChinaDepartment of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, ChinaDepartment of Urology, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai 200433, ChinaDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaObjective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-stage renal disease (ESRD) and in 30 healthy adults. Pre- and postoperative semen specimens of 46 male recipients and 15 male controls were collected and compared. Additional 100 married kidney transplant recipients without children were followed up for 3 years to observe their sexual function and fertility. Results. Serum PRL, LH, and T or E2 levels gradually restored to the normal ranges in all kidney transplant recipients, and sperm density, motility, viability, and morphology significantly improved in the male recipients 4 months after successful kidney transplantation (P<.05). Thirty-three male recipients (55.93%) reobtained normal erectile function, and 49 kidney transplant recipients (61.25%) had children within the 3-year follow-up period. Conclusion. Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients.http://dx.doi.org/10.4061/2010/612126 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guang-chun Wang Jun-hua Zheng Long-gen Xu Zhi-lian Min You-hua Zhu Jun Qi Qiang-lin Duan |
spellingShingle |
Guang-chun Wang Jun-hua Zheng Long-gen Xu Zhi-lian Min You-hua Zhu Jun Qi Qiang-lin Duan Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients International Journal of Nephrology |
author_facet |
Guang-chun Wang Jun-hua Zheng Long-gen Xu Zhi-lian Min You-hua Zhu Jun Qi Qiang-lin Duan |
author_sort |
Guang-chun Wang |
title |
Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients |
title_short |
Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients |
title_full |
Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients |
title_fullStr |
Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients |
title_full_unstemmed |
Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients |
title_sort |
measurements of serum pituitary-gonadal hormones and investigation of sexual and reproductive functions in kidney transplant recipients |
publisher |
Hindawi Limited |
series |
International Journal of Nephrology |
issn |
2090-2158 |
publishDate |
2010-01-01 |
description |
Objective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation.
Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-stage renal disease (ESRD) and in 30 healthy adults. Pre- and postoperative semen specimens of 46 male recipients and 15 male controls were collected and compared. Additional 100 married kidney transplant recipients without children were followed up for 3 years to observe their sexual function and fertility.
Results. Serum PRL, LH, and T or E2 levels gradually restored to the normal ranges in all kidney transplant recipients, and sperm density, motility, viability, and morphology significantly improved in the male recipients 4 months after successful kidney transplantation (P<.05). Thirty-three male recipients (55.93%) reobtained normal erectile function, and 49 kidney transplant recipients (61.25%) had children within the 3-year follow-up period.
Conclusion. Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients. |
url |
http://dx.doi.org/10.4061/2010/612126 |
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