Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients

Objective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-sta...

Full description

Bibliographic Details
Main Authors: Guang-chun Wang, Jun-hua Zheng, Long-gen Xu, Zhi-lian Min, You-hua Zhu, Jun Qi, Qiang-lin Duan
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:International Journal of Nephrology
Online Access:http://dx.doi.org/10.4061/2010/612126
id doaj-eb01f72ce8df417898d27e7b8f24c38b
record_format Article
spelling doaj-eb01f72ce8df417898d27e7b8f24c38b2020-11-25T00:53:20ZengHindawi LimitedInternational Journal of Nephrology2090-21582010-01-01201010.4061/2010/612126612126Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant RecipientsGuang-chun Wang0Jun-hua Zheng1Long-gen Xu2Zhi-lian Min3You-hua Zhu4Jun Qi5Qiang-lin Duan6Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaKidney Transplantation Center, 117th Hospital of PLA, Hangzhou 310013, ChinaDepartment of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, ChinaDepartment of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, ChinaDepartment of Urology, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai 200433, ChinaDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaObjective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-stage renal disease (ESRD) and in 30 healthy adults. Pre- and postoperative semen specimens of 46 male recipients and 15 male controls were collected and compared. Additional 100 married kidney transplant recipients without children were followed up for 3 years to observe their sexual function and fertility. Results. Serum PRL, LH, and T or E2 levels gradually restored to the normal ranges in all kidney transplant recipients, and sperm density, motility, viability, and morphology significantly improved in the male recipients 4 months after successful kidney transplantation (P<.05). Thirty-three male recipients (55.93%) reobtained normal erectile function, and 49 kidney transplant recipients (61.25%) had children within the 3-year follow-up period. Conclusion. Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients.http://dx.doi.org/10.4061/2010/612126
collection DOAJ
language English
format Article
sources DOAJ
author Guang-chun Wang
Jun-hua Zheng
Long-gen Xu
Zhi-lian Min
You-hua Zhu
Jun Qi
Qiang-lin Duan
spellingShingle Guang-chun Wang
Jun-hua Zheng
Long-gen Xu
Zhi-lian Min
You-hua Zhu
Jun Qi
Qiang-lin Duan
Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
International Journal of Nephrology
author_facet Guang-chun Wang
Jun-hua Zheng
Long-gen Xu
Zhi-lian Min
You-hua Zhu
Jun Qi
Qiang-lin Duan
author_sort Guang-chun Wang
title Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
title_short Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
title_full Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
title_fullStr Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
title_full_unstemmed Measurements of Serum Pituitary-Gonadal Hormones and Investigation of Sexual and Reproductive Functions in Kidney Transplant Recipients
title_sort measurements of serum pituitary-gonadal hormones and investigation of sexual and reproductive functions in kidney transplant recipients
publisher Hindawi Limited
series International Journal of Nephrology
issn 2090-2158
publishDate 2010-01-01
description Objective. To investigate changes in serum pituitary-gonadal hormones and restoration of sexual and reproductive functions after successful kidney transplantation. Patients and Methods. Serum pituitary-gonadal hormones before and after kidney transplantation were measured in 78 patients with end-stage renal disease (ESRD) and in 30 healthy adults. Pre- and postoperative semen specimens of 46 male recipients and 15 male controls were collected and compared. Additional 100 married kidney transplant recipients without children were followed up for 3 years to observe their sexual function and fertility. Results. Serum PRL, LH, and T or E2 levels gradually restored to the normal ranges in all kidney transplant recipients, and sperm density, motility, viability, and morphology significantly improved in the male recipients 4 months after successful kidney transplantation (P<.05). Thirty-three male recipients (55.93%) reobtained normal erectile function, and 49 kidney transplant recipients (61.25%) had children within the 3-year follow-up period. Conclusion. Successful kidney transplantation could effectively improve pituitary-gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients.
url http://dx.doi.org/10.4061/2010/612126
work_keys_str_mv AT guangchunwang measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
AT junhuazheng measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
AT longgenxu measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
AT zhilianmin measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
AT youhuazhu measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
AT junqi measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
AT qianglinduan measurementsofserumpituitarygonadalhormonesandinvestigationofsexualandreproductivefunctionsinkidneytransplantrecipients
_version_ 1725237919955812352