An insertion variant of MGMT disrupts a STAT1 binding site and confers susceptibility to glioma

An insertion variant of MGMT disrupts a STAT1 binding site and confers susceptibility to glioma

Abstract Background O 6-methylguanine-DNA methyltransferase (MGMT) is a pivotal enzyme for repairing DNA alkylation damage. Epigenetic modification of MGMT has been well known as a promising prognostic biomarker for glioma. However, the significance of genetic variations of MGMT in glioma carcinogen...

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Bibliographic Details
Main Authors: Liming Huang, Wenshen Xu, Danfang Yan, Xi Shi, Xin You, Jiaqi Xu, Pingping You, Yuanyuan Ke, Lian Dai
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
Glioma
MGMT
Expression quantitative trait locus
STAT1
Susceptibility
Online Access:https://doi.org/10.1186/s12935-021-02211-4

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