Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Abstract Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL...

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Bibliographic Details
Main Authors: Zhuming Chen, Huan Zhong, Jinsong Wei, Sien Lin, Zhixian Zong, Fan Gong, Xinqia Huang, Jinhui Sun, Peng Li, Hao Lin, Bo Wei, Jiaqi Chu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Synovitis
NLRP3
ROS
Nrf2/HO-1 signaling
Online Access:https://doi.org/10.1186/s13075-019-2085-6

Internet

https://doi.org/10.1186/s13075-019-2085-6

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