Association of a single nucleotide polymorphism in the SUR1 gene with type 2 diabetes and obesity in Turkish patients

• Main Authors: Nuriye Uzuncan, Mustafa Kemal Başaralı4, Erkan Söğüt, Enver Sancaktar, Osman Evliyaoglu, Baysal Karaca
• Format: Article
• Language: English
• Published: Modestum Publishing LTD 2011-06-01
• Series: Journal of Clinical and Experimental Investigations
• Subjects: Type 2 diabetes; obesity; SUR1 gene polymorphism; RFLP
• Online Access: http://jceionline.org/upload/sayi/5/JCEI-00539.pdf

Sulfonylurea receptor 1 (SUR1) gene codes the SUR1 protein that plays a key role in glucose-induced insulin secretion. In this study, we have investigated the relationship between the polymorphism in exon 31 of the SUR1 gene and type 2 diabetes, and its association with obesity in Turkish diabetic patients.Materials and methods: 90 patients (45 males and 45 females, aged 43-70 years old) who were followed up in the diabetes outpatient clinic were enrolled in the study. Serum glucose, triglyceride, cholesterol and blood HbA1c levels were determined. The SNPs in exon 31 were examined by a polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) method.Results: A significant increase in the frequency of the A allele was observed in type 2 diabetic patients compared with that of the control group (41% vs. 24%, p<0.01), and this association was stronger in the subgroup of patients with obesity (A allele 44%, p<0.01). There was a significant difference in genotype distribution of exon 31 R1273R SNP between the patients and controls (P=0.01), especially between the patients with obesity and the control group (P=0.007).Conclusion: This study reports that the SNP in exon 31 of the SUR1 gene is strongly associated with type 2 diabetes mellitus in Turkish patients with concomitant obesity, suggesting interactions of SUR1 variants with type 2 diabetes and obesity. J Clin Exp Invest 2011;2(2):161-7