Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety

Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety

New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazid...

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Main Authors: Cristian Peptu, Jacques Desbrieres, Marcel Popa, Valeriu Sunel, Lenuta Profire, Mihaela Moise
Format: Article
Language:English
Published: MDPI AG 2009-07-01
Series:Molecules
Subjects:
phenylalanine
thiosemicarbazide
1
3
4-thiadiazole
2
4-triazole
anti-inflammatory activity
Online Access:http://www.mdpi.com/1420-3049/14/7/2621/
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spelling doaj-eae63aa4d02840b987384e24036a2b992020-11-24T22:26:05ZengMDPI AGMolecules1420-30492009-07-011472621263110.3390/molecules14072621Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine MoietyCristian PeptuJacques DesbrieresMarcel PopaValeriu SunelLenuta ProfireMihaela MoiseNew 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the anti-inflammatory study of the triazole compound 9 established an appreciable anti-inflammatory activity that is comparable with that of other nonsteroidal anti-inflammatory agents. http://www.mdpi.com/1420-3049/14/7/2621/phenylalaninethiosemicarbazide134-thiadiazole124-triazoleanti-inflammatory activity
collection DOAJ
language English
format Article
sources DOAJ
author Cristian Peptu
Jacques Desbrieres
Marcel Popa
Valeriu Sunel
Lenuta Profire
Mihaela Moise
spellingShingle Cristian Peptu
Jacques Desbrieres
Marcel Popa
Valeriu Sunel
Lenuta Profire
Mihaela Moise
Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
Molecules
phenylalanine
thiosemicarbazide
1
3
4-thiadiazole
1
2
4-triazole
anti-inflammatory activity
author_facet Cristian Peptu
Jacques Desbrieres
Marcel Popa
Valeriu Sunel
Lenuta Profire
Mihaela Moise
author_sort Cristian Peptu
title Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_short Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_full Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_fullStr Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_full_unstemmed Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety
title_sort synthesis and biological activity of some new 1,3,4-thiadiazole and 1,2,4-triazole compounds containing a phenylalanine moiety
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2009-07-01
description New 1,3,4-thiadiazole, 6, 7 and 1,2,4-triazole derivatives, 8, 9 containing a phenylalanine moiety have been synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides, 4, 5, in acid and alkaline media, respectively; the thiosemicarbazides were obtained by reaction of hydrazide 3 with appropriate aromatic isothiocyanates. The toxicity of the synthesized compounds was evaluated and the anti-inflammatory study of the triazole compound 9 established an appreciable anti-inflammatory activity that is comparable with that of other nonsteroidal anti-inflammatory agents.
topic phenylalanine
thiosemicarbazide
1
3
4-thiadiazole
1
2
4-triazole
anti-inflammatory activity
url http://www.mdpi.com/1420-3049/14/7/2621/
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AT jacquesdesbrieres synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
AT marcelpopa synthesisandbiologicalactivityofsomenew134thiadiazoleand124triazolecompoundscontainingaphenylalaninemoiety
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