PARODONT-PROTECTIVE ACTION OF ORAL GEL "ARGININE" APPLICATIONS IN RATS WITH INTESTINAL DYSBIOSIS WHICH RECEIVED A HIGH-FAT DIET

• Main Authors: A. V. Borisenko, A. P. Levitsky, A. S. Kuvaev
• Format: Article
• Language: English
• Published: Kazimierz Wielki University 2015-03-01
• Series: Journal of Education, Health and Sport
• Subjects: пародонт, дисбиоз, жировое питание, воспаление, аргинин, оральные гели, periodontal, dysbiosis, fatty food, inflammation, arginine, oral gels.
• Online Access: http://www.ojs.ukw.edu.pl/index.php/johs/article/view/2601

Borisenko A. V., Levitsky A. P., Kuvaev A. S. Пародонтопротекторное действие оральных аппликаций геля «Аргинин» у крыс с кишечным дисбиозом, получавших высокожировой рацион = Parodont-protective action of oral gel "Arginine" applications in rats with intestinal dysbiosis which received a high-fat diet. Journal of Education, Health and Sport. 2015;5(3):294-302. ISSN 2391-8306. DOI: 10.5281/zenodo.16495 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%283%29%3A294-302 https://pbn.nauka.gov.pl/works/552270 http://dx.doi.org/10.5281/zenodo.16495 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive   Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015.   УДК 616.33+342.092       ПАРОДОНТОПРОТЕКТОРНОЕ ДЕЙСТВИЕ ОРАЛЬНЫХ АППЛИКАЦИЙ ГЕЛЯ «АРГИНИН» У КРЫС С КИШЕЧНЫМ ДИСБИОЗОМ, ПОЛУЧАВШИХ ВЫСОКОЖИРОВОЙ РАЦИОН   Parodont-protective action of oral gel "ARGININE" applications in rats with intestinal dysbiosis which received a high-fat diet   А. В. Борисенко1, А. П. Левицкий2, А. С. Куваев1 A. V. Borisenko, A. P. Levitsky, A. S. Kuvaev   1Киевский национальный медицинский университет им. А. А. Богомольца 2ГУ «Институт стоматологии НАМН» (г. Одесса)   1National Medical University named after А. А. Bogomolets, Kiyv 2SE “The Institute of Stomatology of the NAMS of Ukraine” (Odessa, Ukraine)   Abstract   Aim: To determine the periodontal condition at intestinal dysbiosis and high-fat diet (HFD) and the influence of an oral gel containing arginine. Materials and methods: We used a mucous-adhesive phytogel containing cardioarginin (14% on a 4% CMC). Intestinal dysbiosis was obtained using lincomycin (60 mg/kg). HFD was prepared by addition of palm oil to the feed (final fat content in the diet 25%). Dysbiosis was calculated according to the levels of urease and lysozyme, inflammation was expressed in terms of inflammatory markers (MDA and elastase). In the gums there were determined the content of hyaluronic acid and the degree of atrophy of periodontal by Nikolaeva. Gel applications were performed at the dose 0.3 ml / rat daily. Results: Intestinal dysbiosis on the HFD background causes in the development of periodontal dysbiosis, inflammation and tissue recession. Oral gels containing arginine have parodont-protective action.   Key words: periodontal, dysbiosis, fatty food, inflammation, arginine, oral gels.   Реферат   При воспроизведении кишечного дисбиоза на фоне высокожирового рациона в пародонте крыс развивается дисбиоз, воспаление и рецессия тканей. Оральные аппликации геля, содержащего аргинин, оказывают пародонтопротекторное действие, что свидетельствует о важной защитной роли окиси азота, образующейся из аргинина.   Ключевые слова: пародонт, дисбиоз, жировое питание, воспаление, аргинин, оральные гели. ьные гели.