Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study

Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infa...

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Main Authors: Sravan K Reddy, Ranjan Shetty, Srujitha Marupuru, Nishanth Yedavalli, Kiran Shetty
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2017-04-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/9622/24963_CE[Ra1]_F(GH)_PF1(SY_RK)_PFA(P)_PF2(ShGH).pdf
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spelling doaj-ead75c5eaa4449dcad1593dd114873452020-11-25T02:20:01ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-04-01114LC05LC0710.7860/JCDR/2017/24963.9622Significance of Platelet Volume Indices in STEMI Patients: A Case-Control StudySravan K Reddy0Ranjan Shetty1Srujitha Marupuru2Nishanth Yedavalli3Kiran Shetty4Registrar, Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India.Professor and Head, Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India.Intern, Department of Pharmacy Practice, Kasturba Medical College, Manipal, Karnataka, India.Intern, Department of Pharmacy Practice, Kasturba Medical College, Manipal, Karnataka, India.PhD Scholar, Department of Cardiology, Manipal, Karnataka, India.Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive age-matched controls were enrolled. Results: The mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6%) had higher incidence of STEMI then females (25.4%). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132). Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.https://jcdr.net/articles/PDF/9622/24963_CE[Ra1]_F(GH)_PF1(SY_RK)_PFA(P)_PF2(ShGH).pdfgensini scoremean platelet volumemyocardial infarctionprognostic aid
collection DOAJ
language English
format Article
sources DOAJ
author Sravan K Reddy
Ranjan Shetty
Srujitha Marupuru
Nishanth Yedavalli
Kiran Shetty
spellingShingle Sravan K Reddy
Ranjan Shetty
Srujitha Marupuru
Nishanth Yedavalli
Kiran Shetty
Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study
Journal of Clinical and Diagnostic Research
gensini score
mean platelet volume
myocardial infarction
prognostic aid
author_facet Sravan K Reddy
Ranjan Shetty
Srujitha Marupuru
Nishanth Yedavalli
Kiran Shetty
author_sort Sravan K Reddy
title Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study
title_short Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study
title_full Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study
title_fullStr Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study
title_full_unstemmed Significance of Platelet Volume Indices in STEMI Patients: A Case-Control Study
title_sort significance of platelet volume indices in stemi patients: a case-control study
publisher JCDR Research and Publications Private Limited
series Journal of Clinical and Diagnostic Research
issn 2249-782X
0973-709X
publishDate 2017-04-01
description Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive age-matched controls were enrolled. Results: The mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6%) had higher incidence of STEMI then females (25.4%). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132). Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.
topic gensini score
mean platelet volume
myocardial infarction
prognostic aid
url https://jcdr.net/articles/PDF/9622/24963_CE[Ra1]_F(GH)_PF1(SY_RK)_PFA(P)_PF2(ShGH).pdf
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