| Summary: | <h4>Background</h4> Polycystic ovary syndrome (PCOS) is a common gynecological disease that is often accompanied by some metabolic abnormality such as insulin resistance and dyslipidemia. As a non-pharmacological therapy, acupuncture is widely used for the treatment of PCOS, but the effectiveness for insulin resistance and lipid metabolic disorder remains controversial. <h4>Objectives</h4> To assess the effectiveness and safety of acupuncture for insulin resistance and lipid metabolic disorder of women with PCOS. <h4>Search methods</h4> Eight databases will be searched from inception to June 2021, three clinical trial registration platforms will be searched for relevant trials. <h4>Selection criteria</h4> Randomized controlled trials (RCTs) of acupuncture therapy for insulin resistance and lipid metabolic of PCOS will be included. <h4>Data collection and analysis</h4> Study screening, data collection, and analysis will be performed by two or more reviewers independently. We will calculate mean difference (MD), standard mean difference (SMD) with 95% confidence intervals (CIs). Data synthesis will be performed with RevMan V.5.3 software and with Stata V.15.0 software when necessary. <h4>PROSPERO registration number</h4> CRD42020177846
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