Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs.

Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs.

BH3 profiling measures the propensity of transformed cells to undergo intrinsic apoptosis and is determined by exposing cells to BH3-mimicking peptides. We hypothesized that basal levels of prosurvival BCL-2 family proteins may modulate the predictive power of BH3 profiling and termed it mitochondri...

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Main Authors: Jo Ishizawa, Kensuke Kojima, Teresa McQueen, Vivian Ruvolo, Dhruv Chachad, Graciela M Nogueras-Gonzalez, Xuelin Huang, William E Pierceall, E J Dettman, Michael H Cardone, Sharon Shacham, Marina Konopleva, Michael Andreeff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4573975?pdf=render

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http://europepmc.org/articles/PMC4573975?pdf=render

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