A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery

A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery

A Multilayered Multidisk Tablet (MLMDT) comprising two drug-loaded disks enveloped by three drug-free barrier layers was developed for use in chronotherapeutic disorders, employing two model drugs, theophylline and diltiazem HCl. The MLMDT was designed to achieve two pulses of drug release separated...

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Bibliographic Details
Main Authors:	Zaheeda Khan, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Valence M. K. Ndesendo, Viness Pillay
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2013/569470

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