Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy

Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We...

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Bibliographic Details
Main Authors: Matteo Castelli, Andreina Baj, Elena Criscuolo, Roberto Ferrarese, Roberta A. Diotti, Michela Sampaolo, Federica Novazzi, Daniela Dalla Gasperina, Daniele Focosi, Davide Ferrari, Massimo Locatelli, Massimo Clementi, Nicola Clementi, Fabrizio Maggi, Nicasio Mancini
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
variant of concern
L452R
R346K
spike
Online Access:https://www.mdpi.com/1999-4915/13/8/1514

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