Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS

Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by degeneration of upper and lower motor neurons. While the fundamental causes of the disease are still unclear, the accumulation of Cu,Zn-superoxide dismutase (SOD1) immunoreactive aggregates is associated with famili...

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Bibliographic Details
Main Authors: Lucas S. Dantas, Adriano B. Chaves-Filho, Fernando R. Coelho, Thiago C. Genaro-Mattos, Keri A. Tallman, Ned A. Porter, Ohara Augusto, Sayuri Miyamoto
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718303707

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http://www.sciencedirect.com/science/article/pii/S2213231718303707

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