Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Time restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies...

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Main Authors: Leonidas S. Lundell, Evelyn B. Parr, Brooke L. Devlin, Lars R. Ingerslev, Ali Altıntaş, Shogo Sato, Paolo Sassone-Corsi, Romain Barrès, Juleen R. Zierath, John A. Hawley
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18412-w
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spelling doaj-eaaefae39043469f878c4239471fbfba2021-09-19T11:50:41ZengNature Publishing GroupNature Communications2041-17232020-09-0111111110.1038/s41467-020-18412-wTime-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expressionLeonidas S. Lundell0Evelyn B. Parr1Brooke L. Devlin2Lars R. Ingerslev3Ali Altıntaş4Shogo Sato5Paolo Sassone-Corsi6Romain Barrès7Juleen R. Zierath8John A. Hawley9Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenExercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic UniversityExercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic UniversityNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenCenter for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, IrvineCenter for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, IrvineNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenExercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic UniversityTime restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies periodicity in amino acid related metabolites and transporters.https://doi.org/10.1038/s41467-020-18412-w
collection DOAJ
language English
format Article
sources DOAJ
author Leonidas S. Lundell
Evelyn B. Parr
Brooke L. Devlin
Lars R. Ingerslev
Ali Altıntaş
Shogo Sato
Paolo Sassone-Corsi
Romain Barrès
Juleen R. Zierath
John A. Hawley
spellingShingle Leonidas S. Lundell
Evelyn B. Parr
Brooke L. Devlin
Lars R. Ingerslev
Ali Altıntaş
Shogo Sato
Paolo Sassone-Corsi
Romain Barrès
Juleen R. Zierath
John A. Hawley
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Nature Communications
author_facet Leonidas S. Lundell
Evelyn B. Parr
Brooke L. Devlin
Lars R. Ingerslev
Ali Altıntaş
Shogo Sato
Paolo Sassone-Corsi
Romain Barrès
Juleen R. Zierath
John A. Hawley
author_sort Leonidas S. Lundell
title Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
title_short Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
title_full Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
title_fullStr Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
title_full_unstemmed Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
title_sort time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-09-01
description Time restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies periodicity in amino acid related metabolites and transporters.
url https://doi.org/10.1038/s41467-020-18412-w
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