A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins....

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Main Authors: Kee-In Lee, Jin-Soo Hwang, Sun-Ah Lee, In-Taek Hwang
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Molecules
Subjects:
4-arylcoumarins
Kostanecki reaction
DBU
3,4-disubstituted coumarins
one-pot reaction
Online Access:http://www.mdpi.com/1420-3049/16/8/6313/
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spelling doaj-eaad113248854a088eaf43f6e956c95f2020-11-25T01:40:44ZengMDPI AGMolecules1420-30492011-07-011686313632110.3390/molecules16086313A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBUKee-In LeeJin-Soo HwangSun-Ah LeeIn-Taek HwangAn efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.http://www.mdpi.com/1420-3049/16/8/6313/4-arylcoumarinsKostanecki reactionDBU3,4-disubstituted coumarinsone-pot reaction
collection DOAJ
language English
format Article
sources DOAJ
author Kee-In Lee
Jin-Soo Hwang
Sun-Ah Lee
In-Taek Hwang
spellingShingle Kee-In Lee
Jin-Soo Hwang
Sun-Ah Lee
In-Taek Hwang
A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
Molecules
4-arylcoumarins
Kostanecki reaction
DBU
3,4-disubstituted coumarins
one-pot reaction
author_facet Kee-In Lee
Jin-Soo Hwang
Sun-Ah Lee
In-Taek Hwang
author_sort Kee-In Lee
title A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_short A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_full A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_fullStr A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_full_unstemmed A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU
title_sort facile synthesis of highly functionalized 4-arylcoumarins via kostanecki reactions mediated by dbu
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2011-07-01
description An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.
topic 4-arylcoumarins
Kostanecki reaction
DBU
3,4-disubstituted coumarins
one-pot reaction
url http://www.mdpi.com/1420-3049/16/8/6313/
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