The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes

In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discusse...

Full description

Bibliographic Details
Main Authors:	Marta S. Krawczyk, Adam Sroka, Irena Majerz
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Molecules
Subjects:	fenamic acids acridine complex QTAIM NCI approach
Online Access:	https://www.mdpi.com/1420-3049/26/10/2956

id	doaj-eaaae85f4446424ebd074cfbf1345e04
record_format	Article
spelling	doaj-eaaae85f4446424ebd074cfbf1345e042021-06-01T00:10:49ZengMDPI AGMolecules1420-30492021-05-01262956295610.3390/molecules26102956The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine ComplexesMarta S. Krawczyk0Adam Sroka1Irena Majerz2Faculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, PolandFaculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, PolandFaculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, PolandIn order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O–H<sup>…</sup>N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as π<sup>…</sup>π stacking, C–H<sup>…</sup>X (X = O, Cl) intermolecular hydrogen bonds as well as C–H<sup>…</sup>π and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches.https://www.mdpi.com/1420-3049/26/10/2956fenamic acidsacridinecomplexQTAIMNCI approach
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marta S. Krawczyk Adam Sroka Irena Majerz
spellingShingle	Marta S. Krawczyk Adam Sroka Irena Majerz The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes Molecules fenamic acids acridine complex QTAIM NCI approach
author_facet	Marta S. Krawczyk Adam Sroka Irena Majerz
author_sort	Marta S. Krawczyk
title	The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
title_short	The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
title_full	The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
title_fullStr	The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
title_full_unstemmed	The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes
title_sort	crystal structure and intermolecular interactions in fenamic acids–acridine complexes
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-05-01
description	In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O–H<sup>…</sup>N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as π<sup>…</sup>π stacking, C–H<sup>…</sup>X (X = O, Cl) intermolecular hydrogen bonds as well as C–H<sup>…</sup>π and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches.
topic	fenamic acids acridine complex QTAIM NCI approach
url	https://www.mdpi.com/1420-3049/26/10/2956
work_keys_str_mv	AT martaskrawczyk thecrystalstructureandintermolecularinteractionsinfenamicacidsacridinecomplexes AT adamsroka thecrystalstructureandintermolecularinteractionsinfenamicacidsacridinecomplexes AT irenamajerz thecrystalstructureandintermolecularinteractionsinfenamicacidsacridinecomplexes AT martaskrawczyk crystalstructureandintermolecularinteractionsinfenamicacidsacridinecomplexes AT adamsroka crystalstructureandintermolecularinteractionsinfenamicacidsacridinecomplexes AT irenamajerz crystalstructureandintermolecularinteractionsinfenamicacidsacridinecomplexes
_version_	1721415612998090752

The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes

Similar Items