The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain

The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain

In the majority of patients with breast cancer in the advanced stages, skeletal metastases are common, which may cause excruciating pain. Currently available drug treatments for relief of breast cancer-induced bone pain (BCIBP) include non-steroidal anti-inflammatory drugs and strong opioid analgesi...

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Bibliographic Details
Main Authors: Priyank A. Shenoy, Andy Kuo, Nemat Khan, Louise Gorham, Janet R. Nicholson, Laura Corradini, Irina Vetter, Maree T. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
J-2156
somatostatin receptor 4 agonist
mechanical hypersensitivity
mechanical allodynia
mechanical hyperalgesia
Walker 256 cells
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00495/full

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