Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer

Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer

Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for ea...

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Main Authors: Charles E. Carraher, Michael R. Roner, Jessica Frank, Alica Moric-Johnson, Lindsey C. Miller, Kendra Black, Paul Slawek, Francesca Mosca, Jeffrey D. Einkauf, Floyd Russell
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Processes
Subjects:
Group 4 metallocenes
anticancer
poly(ethylene glycol)
pancreatic cancer
breast cancer
prostate cancer
interfacial polycondensation
Group 4 metallocene polymers
organotin polyethers
Online Access:https://www.mdpi.com/2227-9717/5/3/50
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spelling doaj-eaa00601ca5f4a0bbe2c4040cad2e31b2020-11-24T21:53:02ZengMDPI AGProcesses2227-97172017-09-01535010.3390/pr5030050pr5030050Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit CancerCharles E. Carraher0Michael R. Roner1Jessica Frank2Alica Moric-Johnson3Lindsey C. Miller4Kendra Black5Paul Slawek6Francesca Mosca7Jeffrey D. Einkauf8Floyd Russell9Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USADepartment of Biology, University of Texas Arlington, Arlington, TX 76010, USADepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USADepartment of Biology, University of Texas Arlington, Arlington, TX 76010, USADepartment of Biology, University of Texas Arlington, Arlington, TX 76010, USADepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USADepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USADepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USADepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USADepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USAWater-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.https://www.mdpi.com/2227-9717/5/3/50Group 4 metallocenesanticancerpoly(ethylene glycol)pancreatic cancerbreast cancerprostate cancerinterfacial polycondensationGroup 4 metallocene polymersorganotin polyethers
collection DOAJ
language English
format Article
sources DOAJ
author Charles E. Carraher
Michael R. Roner
Jessica Frank
Alica Moric-Johnson
Lindsey C. Miller
Kendra Black
Paul Slawek
Francesca Mosca
Jeffrey D. Einkauf
Floyd Russell
spellingShingle Charles E. Carraher
Michael R. Roner
Jessica Frank
Alica Moric-Johnson
Lindsey C. Miller
Kendra Black
Paul Slawek
Francesca Mosca
Jeffrey D. Einkauf
Floyd Russell
Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
Processes
Group 4 metallocenes
anticancer
poly(ethylene glycol)
pancreatic cancer
breast cancer
prostate cancer
interfacial polycondensation
Group 4 metallocene polymers
organotin polyethers
author_facet Charles E. Carraher
Michael R. Roner
Jessica Frank
Alica Moric-Johnson
Lindsey C. Miller
Kendra Black
Paul Slawek
Francesca Mosca
Jeffrey D. Einkauf
Floyd Russell
author_sort Charles E. Carraher
title Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
title_short Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
title_full Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
title_fullStr Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
title_full_unstemmed Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
title_sort synthesis of water-soluble group 4 metallocene and organotin polyethers and their ability to inhibit cancer
publisher MDPI AG
series Processes
issn 2227-9717
publishDate 2017-09-01
description Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.
topic Group 4 metallocenes
anticancer
poly(ethylene glycol)
pancreatic cancer
breast cancer
prostate cancer
interfacial polycondensation
Group 4 metallocene polymers
organotin polyethers
url https://www.mdpi.com/2227-9717/5/3/50
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