NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL
Purpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma. Materials and methods: One hundred and thirteen surgical specim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Tomsk National Research Medical Center of the Russian Academy of Sciences
2016-02-01
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| Series: | Sibirskij Onkologičeskij Žurnal |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/143 |
| Summary: | Purpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma. Materials and methods: One hundred and thirteen surgical specimens of squamous cell lung cancer were studied using double staining for Ki-67 antigen (MIB-1 clone, DAKO) by immunohistochemistry and for Ag-ЯОР-proteins with silver nitrate. results: In squamous cell carcinoma, the Ag-NOR area in Ki-67 positive cells correlated with the clinical and morphological parameters: parameter T, the greatest tumor size, parameter N, stage of the disease and tumor differentiation. When the area of Ag-ЯОР-proteins in Ki-67 positive cells was small, the long-term survival rates were higher. The Ag-ЯОР area in Ki-67 positive cells is an independent prognostic factor in squamous cell lung cancer. |
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| ISSN: | 1814-4861 2312-3168 |