In vitro characterization of luseogliflozin, a potent and competitive sodium glucose co-transporter 2 inhibitor: Inhibition kinetics and binding studies

In vitro characterization of luseogliflozin, a potent and competitive sodium glucose co-transporter 2 inhibitor: Inhibition kinetics and binding studies

In this study, we evaluated an inhibition model of luseogliflozin on sodium glucose co-transporter 2 (SGLT2). We also analyzed the binding kinetics of the drug to SGLT2 protein using [3H]-luseogliflozin. Luseogliflozin competitively inhibited human SGLT2 (hSGLT2)-mediated glucose uptake with a Ki va...

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Bibliographic Details
Main Authors: Saeko Uchida, Akiko Mitani, Emi Gunji, Teisuke Takahashi, Koji Yamamoto
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Sodium glucose co-transporter 2 inhibitor
Inhibition model
Binding kinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315000742

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http://www.sciencedirect.com/science/article/pii/S1347861315000742

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