Dynamics of platelet ultrastructural changes under correction of arterial blood pressure with losartan in patients with diabetes mellitus in a subcompensation

• Main Author: Pertseva N.O.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2012-01-01
• Series: Морфологія
• Subjects: diabetes mellitus type 2; subcompensation; arterial hypertension; platelets ultrastructure; losartan
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2012-06-03/12pnotfs.pdf

We have conducted a quantitative evaluation of ultrastructural changes in the dynamics of platelets in the patients with diabetes mellitus type 2 in a subcompensation phase with arterial hypertension under correction of arterial blood pres-sure with losartan and with considering of microalbuminuria. Itis shown that in the patients without the renal complications observed a damage of thrombocyte hemostasis, as a result of this is a significant increase in the relative amount of activated platelets with rising of content degranulated forms with an imbalance of granules and reduction of the mitochondrial apparatus. Inclusion of losartan in the treatment makes it possible to reduce the degree of ultrastructural disorders of platelets from the 6th month of the treatment. In the patients with microalbuminuria showed a strong damage of thrombocyte hemostasis due to significant growth in the content ofthe activated, degranulated and aggregated forms of platelets and development of hyperactivation of platelets by hyaline type. The standard treatment for one year is accompanied by increasing imbalance of granulomer of most platelets and the degree of the heteromorphic pool with a highercontent of degranulated and aggregated forms. Losartan usage limits the enlargement of ultrastructural disorders and leads to significant reduction of platelet degranulation.