EXTRACELLULAR MATRIX: A DYNAMIC NETWORK INVOLVED IN THE STEM CELL REGULATION

• Main Authors: Lambis-Anaya Lina, Suárez-Causado Amileth
• Format: Article
• Language: Spanish
• Published: Universidad de Cartagena 2015-12-01
• Series: Revista Ciencias Biomédicas
• Subjects: Extracellular matrix; Stem cell; Stem cell niche; Bioengineering; Hematopoietic stem cells
• Online Access: http://revistas.unicartagena.edu.co/index.php/cienciasbiomedicas/article/view/1299/1209

Introduction: extracellular matrix (ECM) is a multifunctional network, dynamic and complex with specific biophysics, mechanic, and biochemical properties for each tissue, which function is to regulate the cellular behavior. Stem cells play an important role in the tissue maintenance and regeneration and they are found in a specific microenvironment, defined as niche, in which the ECM can modulate the proliferation, self-renewal and differentiation. Objective: to highlight the function of the ECM in regulating the stem cells behavior and the labor of the ECM-stem cell interaction in the properties and homeostasis of the niche in which they reside. Material and methods: electronic search in the databases: PubMed, ScienceDirect, Scopus and Medline of review and original articles mostly published between 2008 and 2015. Results: 150 articles were obtained, from which 44 documents were used for convenience including review articles and original articles. Conclusion: ECM is a fundamental network that guides the differentiation, proliferation and self-renewal of stem cells, while exerting interaction of these cells with the niches where they reside. The key role of ECM in the interrelation of stem cells with their niche has led to the emergence of bioengineering tools that open up possibilities in the therapy, repair and physiological regeneration of organs. Rev.cienc.biomed.2015;6(2):333-339 KEYWORDS Extracellular matrix; Stem cell; Stem cell niche; Bioengineering; Hematopoietic stem cells.