Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs mi...

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Main Authors:	Ayoub Charehbili, Duveken B. Y. Fontein, Judith R. Kroep, Gerrit-Jan Liefers, Johannes W. R. Nortier, Cornelis J. H. van de Velde
Format:	Article
Language:	English
Published:	MDPI AG 2013-10-01
Series:	Journal of Clinical Medicine
Subjects:	bisphosphonates zoledronic acid chemotherapy neoadjuvant postmenopausal
Online Access:	http://www.mdpi.com/2077-0383/2/4/188

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spelling	doaj-ea6c325ec42f4f55a36c75ebaa51a4d62020-11-24T22:14:27ZengMDPI AGJournal of Clinical Medicine2077-03832013-10-012418820010.3390/jcm2040188Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?Ayoub CharehbiliDuveken B. Y. FonteinJudith R. KroepGerrit-Jan LiefersJohannes W. R. NortierCornelis J. H. van de VeldeThe antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer.http://www.mdpi.com/2077-0383/2/4/188bisphosphonateszoledronic acidchemotherapyneoadjuvantpostmenopausal
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ayoub Charehbili Duveken B. Y. Fontein Judith R. Kroep Gerrit-Jan Liefers Johannes W. R. Nortier Cornelis J. H. van de Velde
spellingShingle	Ayoub Charehbili Duveken B. Y. Fontein Judith R. Kroep Gerrit-Jan Liefers Johannes W. R. Nortier Cornelis J. H. van de Velde Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy? Journal of Clinical Medicine bisphosphonates zoledronic acid chemotherapy neoadjuvant postmenopausal
author_facet	Ayoub Charehbili Duveken B. Y. Fontein Judith R. Kroep Gerrit-Jan Liefers Johannes W. R. Nortier Cornelis J. H. van de Velde
author_sort	Ayoub Charehbili
title	Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_short	Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_full	Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_fullStr	Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_full_unstemmed	Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
title_sort	can zoledronic acid be beneficial for promoting tumor response in breast cancer patients treated with neoadjuvant chemotherapy?
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2013-10-01
description	The antitumor effect of bisphosphonates (BPs) is under increasing scrutiny. Preclinical and clinical evidence has shown that BPs might sensitize breast tumors to chemotherapy. Here, we present a review of current preclinical and clinical evidence for antitumor effects of BPs, and evaluate how BPs might play a role in neoadjuvant treatment of women with breast cancer.
topic	bisphosphonates zoledronic acid chemotherapy neoadjuvant postmenopausal
url	http://www.mdpi.com/2077-0383/2/4/188
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Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?

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