A Systematic Review of Genotype–Phenotype Correlation across Cohorts Having Causal Mutations of Different Genes in ALS

A Systematic Review of Genotype–Phenotype Correlation across Cohorts Having Causal Mutations of Different Genes in ALS

Amyotrophic lateral sclerosis is a rare and fatal neurodegenerative disease characterised by progressive deterioration of upper and lower motor neurons that eventually culminates in severe muscle atrophy, respiratory failure and death. There is a concerning lack of understanding regarding the mechan...

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Bibliographic Details
Main Authors: Owen Connolly, Laura Le Gall, Gavin McCluskey, Colette G Donaghy, William J Duddy, Stephanie Duguez
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Journal of Personalized Medicine
Subjects:
ALS
MND
ALS variants
genotype–phenotype
ALS genes
Online Access:https://www.mdpi.com/2075-4426/10/3/58

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